How Long Does Urolithin A Take to Work?

Urolithin A can produce measurable mitochondrial-related changes within about four weeks, but strength, endurance and physical-function outcomes are usually studied over longer periods. Here’s what human trials actually show.

Reviewed by the Celnovix Editorial Team
Last reviewed: September 2026

If you start taking Urolithin A, how long should you expect to wait before it “works”?

A week?

A month?

Three months?

The answer depends almost entirely on what you mean by:

work.

Human Urolithin A studies have measured very different outcomes, including:

  • Blood metabolites
  • Mitochondrial gene expression
  • Mitophagy-related proteins
  • Muscle endurance
  • Muscle strength
  • Walking distance
  • Aerobic capacity

Those outcomes do not change on the same timeline.

Current human research suggests that measurable mitochondrial-related biological changes can appear after approximately:

4 weeks

of regular supplementation.

Functional outcomes involving muscle endurance and physical performance have generally been evaluated over:

2–4 months.

But there is no scientifically established point at which every person should:

  • Feel more energetic
  • Become stronger
  • Walk farther
  • Recover faster
  • “Feel younger”

That distinction is important.


How Long Does Urolithin A Take to Work? Quick Answer

Based on published human trials:

Outcome

Research Timeline

Urolithin A appears in circulation

Hours after ingestion

Mitochondrial-related biomarker changes

Around 4 weeks

Muscle endurance

Changes reported by ~2–4 months

Muscle strength

Studied mainly over ~4 months

Walking performance

Studied over ~4 months

Aerobic performance

Studied over ~4 months

Long-term healthy-aging outcomes

Not established

Lifespan effects

Not established in humans

So a reasonable evidence-based summary is:

Biological activity can be measured relatively quickly, but meaningful physical outcomes—if they occur—are generally studied over weeks to months rather than days.


Urolithin A Starts Being Absorbed Much Faster Than It “Works”

The first thing to distinguish is:

absorption

from:

clinical effect.

Urolithin A does not need four weeks just to enter the bloodstream.

Human pharmacokinetic research shows that orally consumed Urolithin A is:

bioavailable.

It can be detected in circulation following supplementation.

But appearing in the blood does not automatically mean:

  • Muscle function improves immediately
  • Mitochondria have been remodeled
  • Physical performance changes

Those processes occur on different timelines.


What Happens in the First Few Hours?

After oral supplementation, Urolithin A is absorbed and metabolized.

Researchers can measure:

  • Urolithin A
  • Urolithin-related metabolites
  • Conjugated metabolites

in blood.

This demonstrates:

exposure.

It does not establish that you should feel a noticeable effect that same day.


Should You Feel Urolithin A on the First Day?

Probably not in any predictable way.

Urolithin A is not:

  • Caffeine
  • A stimulant
  • A pre-workout compound
  • A sedative

Its research focus is primarily:

mitochondrial quality-control biology.

That type of mechanism is very different from compounds that create an immediate:

  • Energy sensation
  • Mood change
  • Heart-rate effect

So:

“I didn’t feel anything after taking it”

does not tell you whether mitochondrial-related pathways were affected.


What Happens After About 4 Weeks?

This is where human evidence becomes more interesting.

The first-in-human Urolithin A study included healthy sedentary older adults.

Participants received repeated daily doses including:

  • 500 mg/day
  • 1,000 mg/day

for:

four weeks.

Researchers found changes in:

  • Plasma acylcarnitines
  • Skeletal-muscle mitochondrial gene expression

These findings were interpreted as a:

molecular signature consistent with improved mitochondrial and cellular health.

View the study on PubMed


Does That Mean Urolithin A “Works” in 4 Weeks?

It depends on your definition.

At approximately four weeks, human research supports:

measurable biological activity.

It does not prove that everyone will experience:

  • More energy
  • Better strength
  • Better endurance
  • Improved mobility

after exactly four weeks.

Biomarkers and physical outcomes are different.


Biomarker Changes vs Feeling a Difference

This is one of the most important concepts in supplement research.

Imagine a study finds changes in:

mitochondrial gene expression.

That tells researchers something happened at the biological level.

But it does not automatically mean someone:

feels better.

Likewise, changes in:

  • Acylcarnitines
  • Mitophagy-related proteins
  • Mitochondrial gene expression

are scientifically meaningful without necessarily producing a noticeable subjective sensation.


When Might Muscle Endurance Change?

One important randomized trial studied adults aged:

65–90.

Participants took:

1,000 mg Urolithin A per day

or placebo for:

four months.

Muscle endurance was evaluated during the study.

Researchers reported improvements in:

  • Hand muscle endurance
  • Leg muscle endurance

with Urolithin A.

Some endurance-related changes were observed during the:

2–4 month

study period.

View the trial on PubMed


What Does “Muscle Endurance” Mean?

Muscle endurance is not the same as muscle strength.

It refers to:

how long a muscle can continue performing repeated contractions before fatigue.

That means Urolithin A research is not showing:

“Your muscles become much bigger after two months.”

It is studying whether muscle may become:

more resistant to fatigue.


What About Muscle Strength?

A separate randomized trial studied:

88 untrained, overweight middle-aged adults.

Participants received:

  • Placebo
  • 500 mg/day Urolithin A
  • 1,000 mg/day Urolithin A

for:

four months.

Researchers reported improvements in selected measures of:

muscle strength.

The study described approximately:

12% improvement in selected strength measures.

View the study on PubMed

But this result needs context.


Did Everything Improve After Four Months?

No.

The middle-aged trial’s primary endpoint was:

peak power output.

That endpoint did:

not

improve significantly.

So the correct conclusion is not:

“Urolithin A works after four months.”

The more accurate conclusion is:

Some muscle and exercise-related outcomes improved after four months, while others did not.


When Might Walking Performance Change?

Walking performance has been evaluated using the:

six-minute walk test.

This measures how far someone can walk in six minutes.

Both older- and middle-aged adult trials evaluated this outcome over periods lasting approximately:

four months.

However, the evidence is mixed.


What Did the Older-Adult Trial Find?

After four months:

  • The Urolithin A group increased walking distance.
  • The placebo group also improved.

The difference between groups was:

not statistically significant.

So this trial did not establish a clear effect on six-minute walking distance.


What Does the 2026 Meta-Analysis Say?

This question became clearer in 2026.

Researchers pooled available randomized trials of Urolithin A and muscle health.

The review included:

5 randomized controlled trials

with:

236 participants.

For the six-minute walk test, the pooled effect favored Urolithin A by:

17.03 meters.

However:

  • 95% CI: −5.33 to 39.40 m
  • P = 0.135
  • Evidence certainty: low

That means the result was:

not statistically significant.

View the 2026 systematic review on PubMed


What Does This Mean for “How Long Does It Take?”

It means there is currently no evidence-based promise such as:

“Take Urolithin A for 8 weeks and your walking performance will improve.”

The studies suggest:

  • Several weeks may be enough for biological changes.
  • Several months may be required to evaluate physical outcomes.
  • Physical benefits are not guaranteed.

What About Aerobic Endurance?

The middle-aged-adult trial also evaluated aerobic exercise outcomes.

Researchers reported favorable changes involving:

peak oxygen consumption.

This occurred after:

four months.

But because the overall trial contained multiple outcomes and the primary peak-power endpoint was not significant, these findings should be interpreted as:

promising rather than definitive.


What About Highly Trained Athletes?

A newer randomized placebo-controlled study investigated Urolithin A in:

42 competitive male distance runners.

Participants received:

1,000 mg/day

during a:

four-week altitude training camp.

This is important because earlier studies mainly involved:

  • Older adults
  • Middle-aged adults
  • Less-trained populations

The athlete study helps broaden the research population.

But a four-week trial in trained runners should not be generalized to every consumer.

View the study on PubMed


Can Urolithin A Work in One Week?

There is insufficient evidence showing meaningful functional muscle improvements after only:

7 days.

It may already be:

  • Absorbed
  • Metabolized
  • Biologically active

But that is different from demonstrating measurable improvement in:

  • Muscle endurance
  • Strength
  • Physical performance

Can Urolithin A Work in Two Weeks?

Again, there is no strong human evidence establishing:

two weeks

as a reliable timeframe for functional benefit.

Many mitochondrial and muscle adaptations take longer to evaluate.


What About 30 Days?

Thirty days is much more relevant scientifically.

Approximately four weeks of supplementation has produced measurable changes in:

  • Plasma acylcarnitines
  • Skeletal-muscle mitochondrial gene expression

So if “working” means:

producing detectable biological changes,

four weeks is supported by human research.


What About Eight Weeks?

Eight weeks is approximately where researchers begin entering the timeframe in which:

functional muscle outcomes

have been evaluated.

Some endurance outcomes in older adults were assessed during the two-to-four-month intervention period.

But there is no universal rule that everyone should notice an effect by:

week eight.


What About Three Months?

Three months sits within the general timeframe of several human Urolithin A studies.

By this point, researchers may reasonably evaluate outcomes involving:

  • Endurance
  • Physical function
  • Strength
  • Biomarkers

But again:

study duration does not guarantee personal response.


What About Four Months?

Four months currently represents one of the best-studied longer intervention periods for Urolithin A.

Important randomized trials have evaluated:

  • Muscle endurance
  • Muscle strength
  • Physical performance
  • Mitochondrial biomarkers
  • Safety

over approximately:

four months.

So when discussing current human evidence, four months is a more meaningful timeframe than:

a few days.


Does Urolithin A Keep Working Better the Longer You Take It?

Not established.

Current trials do not demonstrate a simple relationship:

longer supplementation = continuously increasing benefit.

It is possible that biological responses:

  • Plateau
  • Differ between individuals
  • Depend on baseline status

Long-term controlled research is limited.


What Happens After Six Months?

We currently have much less randomized evidence beyond approximately:

four months.

That means claims about:

  • Six-month outcomes
  • One-year outcomes
  • Multi-year benefits

are much less certain.


Does Urolithin A Work Immediately for Energy?

There is no strong evidence supporting an immediate stimulant-like energy effect.

Urolithin A research involves:

mitochondrial quality control

rather than acute central-nervous-system stimulation.

So it should not be expected to feel like:

  • Caffeine
  • Nicotine
  • Pre-workout stimulants

What If I Feel More Energy After a Few Days?

That experience may be real.

But one individual’s subjective response cannot establish causality.

Energy is influenced by many factors:

  • Sleep
  • Stress
  • Food intake
  • Hydration
  • Exercise
  • Expectations
  • Other supplements
  • Caffeine

Without controlled comparison, it is difficult to know whether Urolithin A caused the change.


What If I Don’t Feel Anything?

That does not automatically mean:

Urolithin A is doing nothing.

Remember that clinical trials have measured:

  • Gene expression
  • Plasma metabolites
  • Muscle proteins

These are not sensations.

Some supplements affect measurable biology without creating a noticeable feeling.


Should Urolithin A Produce a Noticeable Sensation?

There is no evidence-based requirement that it should.

In fact, claims such as:

“You’ll feel Urolithin A kick in”

are not strongly supported by the nature of the human research.


Does Age Affect How Quickly Urolithin A Works?

Possibly, but we do not yet have enough evidence to establish age-specific response timelines.

Human trials include:

  • Middle-aged adults
  • Adults 65–90
  • Younger trained athletes

But these studies differ too much to conclude:

“People over 60 need exactly X weeks.”


Does Fitness Level Matter?

It may.

A sedentary older adult and a competitive distance runner have very different:

  • Mitochondrial capacity
  • Training status
  • Muscle physiology
  • Exercise adaptation

This could influence how measurable a supplement effect becomes.

The emerging athlete research is therefore valuable.


Does Baseline Mitochondrial Health Matter?

Potentially.

A person with relatively poor mitochondrial function might theoretically respond differently than someone who is:

  • Young
  • Highly trained
  • Metabolically healthy

But this has not been defined well enough to predict individual response.


Does Dose Change How Quickly Urolithin A Works?

Human trials have studied doses including:

  • 500 mg/day
  • 1,000 mg/day

But there is no validated rule that:

1,000 mg works twice as fast as 500 mg.

Dose-response relationships can vary by endpoint.

For a complete dose discussion:

Urolithin A Dosage Guide


Does Taking Urolithin A in the Morning Make It Work Faster?

There is no strong evidence that morning dosing causes faster clinical results.

Consistency is likely more relevant than choosing a specific clock time.

Read:

Best Time to Take Urolithin A: Morning or Night?


Does Taking Urolithin A With Food Make It Work Faster?

There is no strong evidence establishing that taking it with food produces faster functional outcomes.

Product instructions may differ depending on formulation.

But:

faster absorption

and:

better long-term outcome

are not necessarily the same thing.


Does Exercise Make Urolithin A Work Better?

This has not yet been established clearly.

Exercise independently affects:

  • Mitochondrial turnover
  • Muscle strength
  • Exercise capacity
  • Insulin sensitivity

So the interaction between:

exercise + Urolithin A

is scientifically interesting.

But current evidence does not allow us to promise:

synergy.


Can Urolithin A Replace Exercise While You Wait for It to Work?

No.

For muscle and healthy aging, exercise has much stronger evidence.

Especially:

resistance training.

Read:

How to Maintain Muscle Mass After 50


What About Creatine?

If the goal is:

  • Strength
  • Resistance-training performance
  • Lean tissue

creatine currently has substantially more evidence.

Urolithin A addresses a different research area:

mitochondrial quality control.

Read:

Creatine for Healthy Muscle Aging


Urolithin A and Mitophagy: How Long Does That Take?

Human trials cannot easily measure whole-body mitophagy directly in real time.

Instead, researchers examine:

  • Mitochondrial gene expression
  • Mitophagy-related proteins
  • Metabolites
  • Muscle tissue

Four-week human research already shows mitochondrial-related molecular changes.

For the full mechanism:

Urolithin A and Mitophagy: How Does It Actually Work?


Does Mitophagy Mean You’ll Feel Better?

Not necessarily.

Mitophagy is:

a cellular quality-control process.

It is not a feeling.

Improved cellular quality control may or may not translate into:

  • Better endurance
  • Better strength
  • Better health

depending on the person and outcome.


How Long Does Urolithin A Take to Improve Mitochondria?

A scientifically safer answer is:

Mitochondrial-related molecular changes have been observed after approximately four weeks of daily supplementation in humans.

That is different from saying:

“Your mitochondria are completely repaired in four weeks.”

The latter is not supported.


How Long Does Urolithin A Take to Improve Muscle Endurance?

Human evidence suggests that muscle-endurance outcomes may become measurable over:

approximately 2–4 months.

But not every participant benefits equally.

And current evidence is still limited.


How Long Does Urolithin A Take to Increase Strength?

Selected strength improvements were reported after:

four months

in a middle-aged-adult trial.

That does not establish four months as a guaranteed strength timeline.


How Long Does Urolithin A Take to Help Walking?

There is no established timeline because current walking evidence remains:

inconclusive.

The 2026 meta-analysis found a directionally favorable pooled effect, but it was not statistically significant.


How Long Does Urolithin A Take for Healthy Aging?

There is currently no validated answer.

“Healthy aging” is not a single measurable outcome.

It can include:

  • Strength
  • Mobility
  • Cardiovascular health
  • Metabolism
  • Cognitive function
  • Independence

Human trials do not establish a universal period after which Urolithin A produces:

healthy-aging benefits.


Does Urolithin A Reverse Aging After a Certain Number of Months?

No.

Urolithin A has not been proven to:

  • Reverse biological age
  • Reverse chronological aging
  • Extend human lifespan

regardless of how long it is taken.


How Long Should You Try Urolithin A?

There is no medically established universal trial period.

What can be said from published research is:

  • Four weeks is enough to observe selected biological changes.
  • Two to four months is a common timeframe for muscle-related study outcomes.
  • Evidence beyond several months is much more limited.

That is evidence context—not an individualized recommendation.


How Do You Know Whether Urolithin A Is Working?

This depends on your goal.

If Your Goal Is “Mitochondrial Health”

This is difficult to assess subjectively.

There is no simple home test that tells you:

your mitophagy improved.

If Your Goal Is Physical Function

Track objective measures such as:

  • Walking pace
  • Training performance
  • Repetition endurance
  • Strength

But remember that exercise itself strongly affects these outcomes.

If Your Goal Is Energy

Subjective energy is highly variable and can be influenced by many unrelated factors.


Don’t Change Five Things at Once

If you simultaneously start:

  • Urolithin A
  • Creatine
  • NMN
  • A new exercise program
  • A new diet

and feel better six weeks later, it becomes impossible to know:

which intervention mattered.

This is one reason controlled trials are valuable.


Does Urolithin A Work for Everyone?

No human supplement works identically for everyone.

Response may vary with:

  • Age
  • Genetics
  • Baseline health
  • Exercise status
  • Diet
  • Medication use
  • Dose
  • Adherence

Current trials are too small to reliably identify:

responders vs nonresponders.


Can You Take Urolithin A Every Day While Waiting for Results?

Daily dosing is how most important clinical trials have administered Urolithin A.

Published studies include daily dosing for:

  • Four weeks
  • Several months

Short- to medium-term tolerability has generally been favorable.

For the complete safety discussion:

Urolithin A Side Effects: Is It Safe to Take Daily?


When Should You Stop Waiting for It to “Kick In”?

The idea of a supplement “kicking in” is not particularly appropriate for Urolithin A.

The evidence does not support a single moment at which the effect suddenly begins.

A better model is:

absorption

molecular exposure

cellular signaling

possible physiological adaptation

possible functional outcome

Each step takes a different amount of time.


A More Useful Urolithin A Timeline

Day 1

What may happen

  • Absorption
  • Circulating metabolites

What is not established

  • Noticeable muscle benefit
  • Improved endurance
  • Age reversal

Week 1–2

What may happen

  • Continued biological exposure

Evidence limitation

There is little evidence establishing meaningful functional benefits this early.


Around Week 4

Human evidence supports

Changes in:

  • Plasma acylcarnitines
  • Mitochondrial gene expression
  • Selected mitochondrial-related biomarkers

This is the strongest evidence-based early milestone.


Around Month 2

Human trials begin showing signals involving

  • Muscle endurance

But the evidence is not universal.


Months 3–4

Major trials have evaluated

  • Muscle endurance
  • Muscle strength
  • Walking performance
  • Aerobic performance
  • Mitochondrial biomarkers
  • Safety

This is currently the most important clinical-study window.


Beyond Month 4

Major uncertainty increases

We have much less controlled evidence about:

  • Long-term benefits
  • Long-term safety
  • Whether effects continue increasing
  • Whether benefits persist after stopping

Evidence Summary

Time

What Human Research Supports

Hours

Urolithin A exposure and metabolism

Days

No established functional benefit timeline

~4 weeks

Mitochondrial-related biomarker changes

~2 months

Selected muscle-endurance signals

~4 months

Strength/endurance/performance outcomes studied

>4 months

Limited controlled evidence

Years

Long-term clinical benefits not established


What the 2026 Evidence Changes

The latest systematic review is important because it prevents us from over-interpreting individual positive trials.

Across five randomized trials:

  • Muscle outcomes varied.
  • Study populations differed.
  • Doses differed.
  • Measurement methods differed.
  • Most endpoints could not be pooled.

Only the:

six-minute walk test

could be quantitatively combined.

Even then, the pooled result remained:

statistically inconclusive.

Therefore:

There is no evidence-based countdown clock for Urolithin A.


The Bottom Line

So, how long does Urolithin A take to work?

The best answer from current human evidence is:

Within hours

Urolithin A can be absorbed and appear in circulation.

Around 4 weeks

Human trials have detected changes in mitochondrial-related:

  • Metabolites
  • Gene expression

Around 2–4 months

Researchers have observed selected changes in:

  • Muscle endurance
  • Muscle strength
  • Exercise-related outcomes

But

Not every clinical endpoint improves.

And not every person should expect a noticeable subjective effect.

The most accurate 2026 conclusion is:

Urolithin A shows measurable biological activity within approximately four weeks, while potential muscle and physical-function effects have generally been studied over two to four months. There is no proven universal timeframe for feeling a benefit.

That distinction matters.

A supplement can:

affect biology

without creating an immediate sensation.

And an interesting mechanism does not guarantee:

meaningful clinical improvement.


Frequently Asked Questions

How quickly does Urolithin A start working?

Urolithin A is absorbed much sooner, but mitochondrial-related biomarker changes have been demonstrated after approximately four weeks of regular supplementation.

Can you feel Urolithin A immediately?

There is no evidence that Urolithin A should produce an immediate noticeable sensation.

Does Urolithin A work in one week?

There is insufficient human evidence showing meaningful muscle or physical-function benefits within one week.

Does Urolithin A work after one month?

Human studies have shown mitochondrial-related biomarker changes after approximately four weeks.

How long does Urolithin A take to improve endurance?

Selected endurance improvements have been reported within two-to-four-month clinical trials.

How long does Urolithin A take to improve strength?

Selected strength improvements were observed after four months in one randomized middle-aged-adult trial.

How long does Urolithin A take to improve mitochondria?

Mitochondrial-related molecular changes have been observed after approximately four weeks. This does not mean mitochondria are completely “repaired” in four weeks.

How long should you take Urolithin A?

There is no universally established duration. Clinical trials have commonly studied daily use from four weeks to four months.

Does Urolithin A work better the longer you take it?

That has not been established. Longer use does not necessarily mean continuously increasing benefit.

What if I don’t feel anything after a month?

Lack of a subjective feeling does not prove lack of biological activity. Urolithin A is not a stimulant and many measured outcomes are cellular or metabolic.

Does Urolithin A give you more energy?

Human research does not establish a predictable stimulant-like energy effect.

Can Urolithin A reverse aging in four months?

No. Urolithin A has not been proven to reverse human aging or extend human lifespan.


Related Celnovix Guides


References

Andreux PA, et al.

The Mitophagy Activator Urolithin A Is Safe and Induces a Molecular Signature of Improved Mitochondrial and Cellular Health in Humans

Healthy sedentary older adults received Urolithin A in the first major human clinical study.

Repeated:

  • 500 mg/day
  • 1,000 mg/day

supplementation for four weeks altered:

  • Plasma acylcarnitines
  • Skeletal-muscle mitochondrial gene expression

These findings demonstrate relatively early mitochondrial-related target engagement.

View the study on PubMed


Liu S, et al.

Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial

This randomized study involved:

66 adults aged 65–90.

Participants received:

1,000 mg/day

or placebo for:

four months.

Selected muscle-endurance outcomes improved, while the primary six-minute walk and maximal ATP-production outcomes did not significantly differ from placebo.

View the study on PubMed


Singh A, et al.

Urolithin A Improves Muscle Strength, Exercise Performance, and Biomarkers of Mitochondrial Health in a Randomized Trial in Middle-Aged Adults

This randomized trial included:

88 middle-aged adults

who received placebo, 500 mg/day or 1,000 mg/day for:

four months.

Selected strength, aerobic and mitochondrial outcomes improved.

However, the primary peak-power endpoint did not improve significantly.

The study had industry sponsorship and disclosed company relationships.

View the study on PubMed


Dao T, et al.

Effects of Urolithin A Supplementation on Muscle Health Outcomes in Humans From Randomized Controlled Trials

This 2026 systematic review included:

5 randomized trials and 236 participants.

Only the six-minute walk test could be quantitatively pooled.

The pooled effect was:

+17.03 meters

but was statistically inconclusive and rated:

low certainty

using GRADE.

View the 2026 review on PubMed


Evaluating the Impact of Urolithin A Supplementation on Running Performance, Recovery, and Mitochondrial Biomarkers in Highly Trained Male Distance Runners

This double-blind randomized trial involved:

42 competitive male distance runners

who received:

1,000 mg/day

Urolithin A or placebo during a:

four-week altitude-training camp.

The study extends Urolithin A research into highly trained younger athletes, a population distinct from earlier older-adult trials.

View the study on PubMed


Evidence Transparency

Current timing estimates have important limitations:

  • Human trials remain relatively small.
  • Study populations differ considerably.
  • Clinical endpoints vary.
  • Most studies last four months or less.
  • Several foundational trials were industry sponsored.
  • Biological responses do not necessarily produce noticeable symptoms.
  • There is no validated consumer test for “mitophagy improvement.”
  • Long-term response trajectories remain uncertain.

Celnovix therefore does not present a fixed:

“Urolithin A works in X days”

promise.


Editorial Standards

Celnovix distinguishes between:

  1. Absorption
  2. Biomarker changes
  3. Functional outcomes
  4. Subjective experience
  5. Proven clinical benefit

These are not interchangeable.

We prioritize:

  • Human randomized trials
  • Systematic reviews
  • Primary endpoints
  • Evidence-certainty assessments
  • Transparent discussion of study limitations and conflicts of interest

Medical Disclaimer

This article is provided for general educational and informational purposes only and does not constitute medical advice, diagnosis, treatment or an individualized supplement recommendation.

Urolithin A is not established as a treatment for sarcopenia, fatigue, mitochondrial disease or other medical conditions.

Clinical-study doses and durations are included to describe published research and should not automatically be interpreted as personal recommendations.

If you have significant unexplained fatigue, muscle weakness, rapid loss of physical function, a chronic medical condition, are pregnant or breastfeeding, or take prescription medications, seek advice from an appropriately qualified healthcare professional.

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