Reviewed by the Celnovix Editorial Team
Last reviewed: September 2026
Urolithin A has become one of the most discussed compounds in mitochondrial and healthy-aging research.
But before deciding whether to add it to a daily routine, there is a more important question than potential benefits:
Is Urolithin A safe?
Current human research is reasonably reassuring—but still limited.
Randomized clinical trials have studied oral Urolithin A at doses including:
- 500 mg/day
- 1,000 mg/day
for periods lasting up to:
four months.
Across these studies, Urolithin A was generally well tolerated, and researchers did not identify a clear increase in adverse events compared with placebo.
However, that does not mean:
- Side effects are impossible
- Long-term use has been proven completely safe
- Urolithin A has no medication interactions
- Every medical population has been adequately studied
- 1,000 mg/day is appropriate for everyone
This guide examines what human research actually tells us about Urolithin A safety—and where important uncertainties remain.
Urolithin A Safety at a Glance
|
Question |
Current Evidence |
|---|---|
|
Generally well tolerated in human trials? |
Yes, so far |
|
500 mg/day studied? |
Yes |
|
1,000 mg/day studied? |
Yes |
|
Daily use studied? |
Yes |
|
Four months of use studied? |
Yes |
|
Clear increase in adverse events vs placebo? |
Not demonstrated in major RCTs |
|
Serious product-related adverse events established? |
Not in published human trials reviewed here |
|
Liver toxicity established? |
Not demonstrated in current trials |
|
Kidney toxicity established? |
Not demonstrated in current trials |
|
Safety proven beyond several months? |
No |
|
Pregnancy safety established? |
No |
|
Breastfeeding safety established? |
No |
|
Comprehensive medication-interaction data available? |
No |
|
Safe for every medical condition? |
Not established |
The most accurate summary is:
Urolithin A has shown favorable short-term tolerability in the human trials conducted so far, but the human safety database remains relatively small and long-term evidence is limited.
What Is Urolithin A?
Urolithin A is a metabolite associated with the metabolism of:
- Ellagitannins
- Ellagic acid
These compounds occur in foods including:
- Pomegranates
- Walnuts
- Certain berries
But Urolithin A is generally not obtained from food in predictable amounts.
Instead, certain gut bacteria convert dietary precursors into Urolithin A.
The problem is:
not everyone produces it equally well.
Differences in gut microbiota mean that after eating the same ellagitannin-rich foods, people can produce very different amounts of Urolithin A.
For the complete explanation:
What Is Urolithin A? Benefits, Foods, Mitophagy and Human Research
Why Is Urolithin A Studied?
Much of the scientific interest centers on:
mitophagy.
Mitophagy is part of the cellular quality-control system involved in identifying and recycling damaged or dysfunctional mitochondria.
Because mitochondrial function and quality control change with aging, researchers have investigated whether Urolithin A could influence:
- Mitochondrial biomarkers
- Muscle endurance
- Muscle strength
- Physical performance
- Healthy-aging biology
But mechanistic interest does not automatically establish either:
- Clinical effectiveness
- Long-term safety
Both need to be studied separately.
What Side Effects Have Been Reported With Urolithin A?
One of the challenges with answering this question is that current human trials have not identified a consistent Urolithin A-specific side-effect pattern.
A 2024 systematic review examining human Urolithin A research included:
five studies involving approximately 250 healthy participants.
Doses ranged from:
10 to 1,000 mg/day
and study durations ranged from:
28 days to four months.
The review reported that observed adverse events were generally:
mild or moderate and considered unrelated to the intervention.
View the systematic review on PubMed
This is reassuring.
But it is important not to overstate the conclusion.
Does Urolithin A Cause Headaches?
Headaches have appeared among adverse events reported during Urolithin A research.
However, the available evidence does not establish headaches as a predictable Urolithin A-specific side effect.
Clinical trials contain two types of events:
Adverse Event
Something that happens during the study.
Treatment-Related Adverse Event
An event investigators consider plausibly caused by the intervention.
Those are not automatically the same.
A headache occurring while someone is taking Urolithin A does not prove Urolithin A caused the headache.
Does Urolithin A Cause Muscle Pain?
Myalgia—muscle pain—has also appeared among events recorded in Urolithin A studies.
Again, current systematic-review evidence indicates that reported mild-to-moderate events were not considered directly attributable to Urolithin A.
This distinction matters especially because several trials specifically studied:
- Muscle function
- Muscle biopsies
- Physical-performance testing
Some reported musculoskeletal events may therefore relate to study procedures rather than supplementation itself.
Does Urolithin A Cause Stomach Problems?
There is currently no strong evidence establishing gastrointestinal symptoms as a consistent major adverse effect of Urolithin A.
That does not mean digestive symptoms are impossible.
Individuals can respond differently to:
- Active ingredients
- Capsule excipients
- Other ingredients in a formula
If persistent symptoms appear after beginning any supplement, the timing and product formulation should be considered.
Does Urolithin A Cause Nausea?
Current randomized human evidence does not establish nausea as a common, predictable Urolithin A-specific adverse effect.
Internet side-effect lists should therefore be interpreted cautiously unless they distinguish between:
- Events reported during trials
- Events actually attributed to Urolithin A
Does Urolithin A Cause Diarrhea?
There is not currently strong evidence establishing diarrhea as a characteristic Urolithin A side effect.
Again, individual tolerance can differ.
Commercial supplements may also contain other ingredients that influence gastrointestinal tolerance.
What Did the Older-Adult Trial Find About Safety?
One important randomized clinical trial studied:
66 adults aged 65–90.
Participants received:
1,000 mg Urolithin A per day
or placebo for:
four months.
Researchers monitored adverse events during the intervention.
They found:
no statistically significant difference in adverse events between the Urolithin A and placebo groups.
View the randomized clinical trial on PubMed
This is an important finding because:
- Participants were older adults.
- The dose was relatively high.
- Exposure lasted four months.
But 66 participants is still a small safety population compared with the thousands or tens of thousands often needed to identify uncommon adverse effects.
What Did the Middle-Aged Trial Find?
Another randomized, double-blind, placebo-controlled study included:
88 overweight, untrained middle-aged adults.
Participants received:
- Placebo
- 500 mg/day Urolithin A
- 1,000 mg/day Urolithin A
for:
four months.
Researchers reported favorable tolerability at both doses.
Safety monitoring included:
- Vital signs
- Blood chemistry
- Hematology
- Urinalysis
No significant safety differences were observed between the Urolithin A groups and placebo.
An Important Research Transparency Issue
The middle-aged trial was sponsored by:
Amazentis SA, the company associated with the Urolithin A ingredient used in the study.
Several authors were:
- Employees
- Board members
- Scientific advisory board members
of the sponsoring company.
This does not mean the results are invalid.
Industry-sponsored research can still be:
- Randomized
- Placebo-controlled
- Peer reviewed
- Scientifically useful
But funding and conflicts of interest are relevant when evaluating evidence.
Independent replication strengthens confidence.
What Does the 2024 Systematic Review Say?
A 2024 systematic review attempted to evaluate the overall human evidence rather than relying on a single trial.
It included:
five human studies and approximately 250 healthy participants.
Researchers found signals involving:
- Mitochondrial-related gene expression
- Autophagy-related markers
- Fatty-acid oxidation
- Selected muscle outcomes
But Urolithin A did not consistently improve:
- Maximal mitochondrial ATP production
- Mitochondrial biogenesis
- Mitochondrial dynamics
- Anthropometric outcomes
- Cardiovascular outcomes
- Overall physical function
From a safety perspective, reported adverse events were generally mild or moderate and were assessed as unrelated to Urolithin A.
The authors emphasized the need for:
- Larger trials
- Longer trials
- Broader physiological evaluation
That limitation remains important.
What Does the New 2026 Meta-Analysis Add?
A 2026 systematic review and meta-analysis specifically examined randomized controlled trials involving:
Urolithin A and muscle-health outcomes.
The analysis found that pooled improvement in the six-minute walk test was:
directionally favorable but statistically inconclusive.
The certainty of evidence was rated:
low using GRADE.
Other findings involving:
- Strength
- Endurance
- Mitochondrial biomarkers
were considered exploratory or hypothesis-generating rather than definitive proof of efficacy.
View the 2026 systematic review on PubMed
This matters for safety discussions because it changes the risk-benefit context.
A supplement should not be judged only by:
“Is it safe?”
The better question is:
“How strong is the evidence of benefit relative to the remaining uncertainty?”
Is Urolithin A Safe for the Liver?
Current human trials have not demonstrated a consistent hepatotoxicity signal.
In published clinical studies, researchers monitored blood chemistry and did not report clinically meaningful liver abnormalities attributable to Urolithin A.
That is reassuring.
However:
absence of a liver-safety signal in several hundred research participants is not the same as proving zero liver risk across millions of consumers.
People with significant liver disease are also not adequately represented in the existing evidence base.
Does Urolithin A Raise Liver Enzymes?
Current controlled human trials do not establish Urolithin A as a cause of clinically meaningful liver-enzyme elevation.
But if you have:
- Chronic liver disease
- Abnormal ALT or AST
- Cirrhosis
- Active hepatitis
- Multiple medications affecting the liver
healthy-volunteer trial data should not automatically be applied to your situation.
Is Urolithin A Safe for the Kidneys?
Current human trials have not identified a clear kidney-toxicity signal.
Safety testing in clinical studies has included:
- Blood chemistry
- Urinalysis
without clinically meaningful differences attributable to Urolithin A.
But people with advanced kidney disease have not been studied extensively.
Therefore:
“No kidney toxicity detected in trials”
is more accurate than:
“Urolithin A is proven safe for kidney disease.”
Can People With Kidney Disease Take Urolithin A?
There is insufficient evidence to establish a specific safe dose for people with:
- Chronic kidney disease
- Reduced renal function
- Dialysis
This population requires more individualized consideration.
Is Urolithin A Safe for the Heart?
Current clinical research has not identified a major cardiovascular safety signal.
However, Urolithin A is not established as a treatment for:
- Heart disease
- Hypertension
- Atherosclerosis
The 2024 systematic review did not find consistent cardiovascular benefits.
So it should not replace evidence-based cardiovascular management.
Does Urolithin A Affect Blood Pressure?
Current evidence does not establish a clinically meaningful blood-pressure-lowering effect.
If you take medication for:
- Hypertension
- Heart disease
do not assume Urolithin A can replace or modify your treatment.
Does Urolithin A Affect Blood Sugar?
Urolithin A is involved in metabolic research, but it is not an established diabetes treatment.
People using:
- Insulin
- Sulfonylureas
- GLP-1 medications
- Other glucose-lowering therapies
should not assume supplement-medication interactions have been comprehensively studied.
Urolithin A and Medication Interactions
This is one of the largest evidence gaps.
There is currently no comprehensive high-quality database of Urolithin A interactions covering every major medication class.
That means we cannot confidently say:
“Urolithin A has no drug interactions.”
A more accurate statement is:
clinically important interactions have not been comprehensively characterized.
Does Urolithin A Interact With Blood Thinners?
There is insufficient clinical evidence to establish a specific interaction with:
- Warfarin
- Apixaban
- Rivaroxaban
- Clopidogrel
But lack of documented interaction is not the same as proven absence of interaction.
If you use anticoagulant or antiplatelet therapy, individualized professional guidance is appropriate before adding supplements.
Does Urolithin A Interact With Statins?
No major interaction has been established in human clinical trials.
However, formal interaction data remain limited.
This matters because both:
- Muscle symptoms
- Liver-related laboratory monitoring
can already be relevant to statin therapy.
Does Urolithin A Interact With Metformin?
A clinically important interaction has not been established.
But there are insufficient dedicated human interaction trials to conclude that the combination has been comprehensively studied.
Can You Take Urolithin A With NMN?
Many people interested in healthy aging consider combining:
- Urolithin A
- NMN
because the compounds are associated with different biological pathways.
NMN
Primarily studied around:
NAD+ metabolism
Urolithin A
Primarily studied around:
mitophagy and mitochondrial quality control
However:
different mechanisms do not prove synergy.
There is not strong human evidence showing that combining the two produces superior health outcomes.
Read:
Can You Take NMN and Urolithin A Together?
Can You Take Urolithin A With CoQ10?
There is no strong evidence establishing a clinically important incompatibility between Urolithin A and CoQ10.
But there is also insufficient evidence proving that the combination creates special mitochondrial synergy.
Read:
Urolithin A vs CoQ10: What’s the Difference?
Can You Take Urolithin A With Resveratrol?
There is no strong evidence establishing a universal contraindication.
But again:
combining two longevity-related compounds does not prove greater benefit.
Read:
Is 500 mg of Urolithin A Safe?
Human randomized research has studied:
500 mg/day
for approximately:
four months.
The middle-aged adult trial reported favorable tolerability under those conditions.
That supports:
short-term tolerability of 500 mg/day in the studied population.
It does not establish that 500 mg is appropriate for every person.
Is 1,000 mg of Urolithin A Safe?
Human randomized trials have also studied:
1,000 mg/day
for up to:
four months.
Both older-adult and middle-aged-adult studies reported favorable tolerability.
Again, this supports:
short-term safety under clinical-trial conditions.
It does not establish:
- Lifelong safety
- Safety in pregnancy
- Safety in severe chronic disease
- Safety with every medication
Is 2,000 mg of Urolithin A Safe?
There is not enough high-quality human evidence to establish routine safety at:
2,000 mg/day.
Higher does not automatically mean better.
The best-studied contemporary human doses are substantially better represented around:
500–1,000 mg/day.
What About the FDA and Urolithin A?
Urolithin A has been the subject of an FDA:
GRAS Notice — GRN No. 791.
The notice covered specified food uses and levels.
FDA responded that it had:
“no questions”
regarding the notifier’s GRAS conclusion under the intended conditions of use.
However, this distinction is important:
A GRAS notice is not the same as FDA approval of Urolithin A as a drug or treatment.
It does not mean FDA has approved Urolithin A to:
- Treat disease
- Prevent disease
- Reverse aging
- Improve longevity
For regulatory information, see the FDA GRAS notice database.
Does GRAS Mean a Supplement Is Completely Safe?
No.
GRAS relates to the safety of a substance under specified conditions of intended food use.
It should not be interpreted as:
- Approval of every product containing the ingredient
- Proof of every marketing claim
- Proof of lifelong high-dose use
- Approval as a medication
Regulatory language needs to remain precise.
Can You Take Urolithin A Every Day?
Daily administration is well represented in human clinical trials.
Studies have used daily supplementation for:
- 28 days
- Two months
- Four months
Therefore:
daily use has been studied.
But:
lifelong daily use has not.
Those are different conclusions.
Is Long-Term Urolithin A Use Safe?
This remains one of the most important unanswered questions.
Most published human intervention trials last no longer than approximately:
four months.
That means we have substantially less controlled evidence for:
- One year
- Five years
- Ten years
- Lifelong supplementation
Long-term consumer use should not be confused with long-term randomized safety evidence.
Should You Cycle Urolithin A?
There is no established evidence-based cycling schedule.
Protocols such as:
- Five days on, two days off
- Eight weeks on, two weeks off
- Three months on, one month off
have not been established as superior through high-quality human trials.
Do You Build Tolerance to Urolithin A?
Current research has not established a predictable tolerance phenomenon requiring progressively higher doses.
There is no evidence-based rule saying:
“Increase Urolithin A every few months.”
How Long Does Urolithin A Take to Work?
This depends on what outcome you mean.
Clinical trials have evaluated outcomes after:
- Several weeks
- Two months
- Four months
Some muscle-endurance differences were observed after approximately two months in an older-adult trial.
But there is no established timeline for:
- “Feeling younger”
- More energy
- Better recovery
- Anti-aging effects
because those are not validated universal outcomes.
Is Urolithin A Safe for Older Adults?
Older adults have been directly studied.
The randomized trial involving adults aged:
65–90
used:
1,000 mg/day for four months
and reported favorable tolerability.
This is valuable evidence.
However, the participants were:
- Relatively healthy
- Predominantly women
- All White in that particular study
That limits generalizability.
Is Urolithin A Safe After 60?
Available older-adult evidence is encouraging.
But after 60, other considerations become increasingly important:
- Medication use
- Kidney function
- Liver function
- Cardiovascular disease
- Cancer history
- Frailty
- Multiple chronic conditions
Healthy trial participants do not represent every older adult.
Is Urolithin A Safe for Women?
Women have been well represented in some Urolithin A trials.
For example, approximately:
76%
of participants in the older-adult randomized trial were women.
No major female-specific safety signal was identified.
But this does not establish safety during:
- Pregnancy
- Breastfeeding
or every female-specific medical context.
Urolithin A During Pregnancy
There is insufficient human evidence to establish supplemental Urolithin A as safe during pregnancy.
Pregnancy involves major changes in:
- Metabolism
- Hormones
- Placental biology
- Nutrient requirements
Do not extrapolate healthy-adult trial data to pregnancy.
Urolithin A While Breastfeeding
Human evidence is also insufficient during breastfeeding.
There is not enough information about:
- Maternal supplementation
- Breast-milk transfer
- Infant exposure
to establish routine safety.
Urolithin A and Cancer
This is another area where mechanistic enthusiasm should not become medical advice.
Mitophagy and mitochondrial biology are involved in many cellular processes, including cancer biology.
That does not mean Urolithin A:
- Causes cancer
- Prevents cancer
- Treats cancer
Current evidence does not establish any of those claims.
People with active cancer or undergoing cancer treatment should discuss supplements with their oncology team.
Urolithin A and Immune Function
A newer randomized, placebo-controlled trial investigated Urolithin A in:
50 healthy middle-aged adults
using:
1,000 mg/day for 28 days.
Researchers examined:
- T-cell populations
- Immune metabolism
- Mitochondrial-related immune biology
This represents an important expansion of Urolithin A research beyond muscle.
But it should not be interpreted as proving that Urolithin A:
- “Boosts immunity”
- Prevents infection
- Treats immune disease
Immune biology is much more complex.
Can Urolithin A Treat Sarcopenia?
No.
Current research does not establish Urolithin A as a treatment for sarcopenia.
Clinical trials have reported selected findings involving:
- Muscle endurance
- Muscle strength
- Mitochondrial biomarkers
But the new 2026 meta-analysis concluded that the pooled evidence remains limited and uncertain.
For maintaining muscle with age, interventions with stronger evidence include:
- Resistance training
- Adequate protein
- Appropriate calorie intake
- Physical activity
Read:
How to Maintain Muscle Mass After 50
Is Urolithin A Safer Than NMN?
There is not enough direct comparative research to make that claim.
The compounds:
- Have different mechanisms
- Have different research histories
- Have different clinical datasets
There are no robust head-to-head safety trials establishing one as universally safer.
Read:
Who Should Be More Cautious With Urolithin A?
Professional guidance is particularly appropriate if you:
- Are pregnant
- Are breastfeeding
- Have active cancer
- Are receiving cancer treatment
- Have significant liver disease
- Have significant kidney disease
- Take multiple prescription medications
- Have a complex chronic medical condition
This is primarily because these populations have not been adequately represented in existing Urolithin A trials.
When Should You Stop Taking Urolithin A?
Consider stopping the supplement and seeking appropriate medical advice if you develop:
- A severe allergic reaction
- Persistent unexplained symptoms
- Significant gastrointestinal symptoms
- New symptoms temporally associated with supplementation
- A concerning laboratory abnormality
Do not assume every symptom is caused by the supplement.
But do not ignore a reproducible temporal relationship either.
How to Reduce Unnecessary Risk
If you choose to use Urolithin A, several principles can improve decision quality.
1. Check the Actual Dose
Do not assume higher is better.
2. Avoid Proprietary Blends That Hide Amounts
You should know how much active ingredient you are consuming.
3. Consider the Entire Formula
A reaction may come from:
- Urolithin A
- Another active ingredient
- Excipients
- Flavorings
- Other compounds
4. Avoid Making Multiple Supplement Changes at Once
Otherwise, identifying the cause of a reaction becomes difficult.
5. Review Medications
Especially if you have a complex medical history.
6. Keep Expectations Evidence-Based
A supplement does not need to cause a noticeable sensation to have biological activity.
And a noticeable sensation does not prove benefit.
Urolithin A Safety vs Benefits: The Evidence Balance
A reasonable interpretation of the current evidence is:
Safety
Relatively reassuring over the short term.
Biological Activity
Supported.
Muscle Benefits
Promising but not uniformly demonstrated.
Healthy-Aging Benefits
Still under investigation.
Lifespan Extension
Not established in humans.
Long-Term Safety
Insufficiently characterized.
This is a more useful framework than simply labeling Urolithin A:
“safe”
or:
“unsafe.”
The Bottom Line
Human research on Urolithin A safety is encouraging.
Randomized trials have studied:
500–1,000 mg/day
for up to:
four months
without identifying a clear increase in adverse events compared with placebo.
A 2024 systematic review of approximately 250 healthy participants similarly found that reported adverse events were generally mild or moderate and were not considered directly related to Urolithin A.
More recent research continues to expand the human evidence base.
But there are important limits.
We still do not have extensive evidence covering:
- Years of continuous use
- Pregnancy
- Breastfeeding
- Advanced liver disease
- Advanced kidney disease
- Active cancer
- Every medication combination
- Very large and diverse populations
So the evidence-based conclusion is not:
“Urolithin A has no side effects.”
It is:
Urolithin A has demonstrated favorable short-term tolerability in the human populations studied so far, while long-term and population-specific safety questions remain incompletely answered.
That distinction matters.
Especially in healthy-aging science, uncertainty should not be hidden behind marketing language.
Frequently Asked Questions
What are the side effects of Urolithin A?
Current human trials have not identified a consistent Urolithin A-specific side-effect pattern. Reported adverse events have generally been mild or moderate and often considered unrelated to supplementation.
Is Urolithin A safe?
Published human trials generally report favorable short-term tolerability. Long-term safety remains less established.
Is Urolithin A safe to take every day?
Daily dosing has been studied for periods up to approximately four months. Lifelong daily safety has not been established.
Is 500 mg Urolithin A safe?
500 mg/day has been studied for four months in randomized human research with favorable tolerability.
Is 1,000 mg Urolithin A safe?
1,000 mg/day has also been studied for up to four months with favorable tolerability in the populations studied.
Can Urolithin A damage the liver?
Current human trials have not established a liver-toxicity signal, but people with significant liver disease have not been extensively studied.
Can Urolithin A damage the kidneys?
Current trials have not identified a clear kidney-toxicity signal. Evidence in advanced kidney disease remains limited.
Does Urolithin A cause headaches?
Headaches have been reported as adverse events in research, but current evidence does not establish them as a predictable Urolithin A-specific side effect.
Does Urolithin A cause muscle pain?
Myalgia has appeared among reported events, but available systematic-review evidence does not establish it as a consistent treatment-related adverse effect.
Does Urolithin A interact with medications?
Comprehensive medication-interaction data are limited. Absence of a known interaction should not be interpreted as proof that no interaction is possible.
Can pregnant women take Urolithin A?
Supplemental Urolithin A has not been adequately studied during pregnancy.
Can you take Urolithin A while breastfeeding?
Human breastfeeding safety data are insufficient.
Is Urolithin A FDA approved?
Urolithin A has been the subject of an FDA GRAS notice for specified food uses. That is not the same as FDA approval as a drug or treatment.
Can you take Urolithin A with NMN?
The combination is scientifically interesting because the compounds affect different biological pathways, but strong human evidence proving superior combined benefit is lacking.
Related Celnovix Guides
- What Is Urolithin A?
- Urolithin A Benefits
- Urolithin A Dosage Guide
- Best Time to Take Urolithin A
- Foods Rich in Urolithin A
- Urolithin A vs CoQ10
- Urolithin A vs Resveratrol
- NMN vs Urolithin A
- Can You Take NMN and Urolithin A Together?
- How to Maintain Muscle Mass After 50
References
Hodzic Kuerec A, et al.
Targeting Aging With Urolithin A in Humans: A Systematic Review
This 2024 systematic review evaluated five human studies involving approximately 250 healthy participants.
Urolithin A was studied at doses ranging from 10 to 1,000 mg/day for 28 days to four months.
Reported adverse events were generally mild or moderate and considered unrelated to the intervention.
View the systematic review on PubMed
Liu S, et al.
Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial
This randomized trial included 66 adults aged 65–90.
Participants received:
1,000 mg/day Urolithin A
or placebo for:
four months.
No statistically significant difference in adverse events was observed between the groups.
View the randomized clinical trial on PubMed
Singh A, et al.
Urolithin A Improves Muscle Strength, Exercise Performance, and Biomarkers of Mitochondrial Health in a Randomized Trial in Middle-Aged Adults
This randomized trial included 88 middle-aged adults assigned to:
- Placebo
- 500 mg/day Urolithin A
- 1,000 mg/day Urolithin A
for four months.
Both doses were reported as generally well tolerated.
The study was sponsored by Amazentis SA, and several authors disclosed relationships with the sponsor.
Dao MC, et al.
Effects of Urolithin A Supplementation on Muscle Health Outcomes in Humans From Randomized Controlled Trials
Published in 2026, this systematic review and meta-analysis evaluated randomized Urolithin A trials.
The pooled six-minute walk result was directionally favorable but statistically inconclusive, with low GRADE certainty.
Other muscle and mitochondrial findings were considered exploratory.
View the 2026 systematic review on PubMed
U.S. Food and Drug Administration
GRAS Notice No. 791 — Urolithin A
FDA’s GRAS notice database lists Urolithin A under GRN No. 791 for specified food uses and conditions.
The FDA response stated that it had no questions regarding the notifier’s GRAS conclusion.
This should not be interpreted as FDA approval of Urolithin A as a drug or anti-aging treatment.
Evidence Transparency
The Urolithin A evidence base has several important limitations:
- Human sample sizes remain relatively small.
- Most interventions last no longer than four months.
- Some major trials were industry sponsored.
- Participants in several studies were relatively healthy.
- Some populations lack adequate representation.
- Long-term medication-interaction data are limited.
- Long-term safety remains incompletely characterized.
- Positive mechanistic findings should not be interpreted automatically as clinical benefit.
Celnovix distinguishes between:
short-term tolerability
and:
proven long-term safety.
Editorial Standards
Celnovix prioritizes:
- Human randomized controlled trials
- Systematic reviews and meta-analyses
- Authoritative regulatory sources
- Transparent discussion of study limitations
- Disclosure of relevant industry involvement
We do not interpret:
- GRAS status as drug approval
- A mitochondrial biomarker as proof of age reversal
- Short-term tolerability as proof of lifelong safety
- Absence of documented interactions as proof that interactions are impossible
Medical Disclaimer
This article is provided for general educational and informational purposes only and does not constitute medical advice, diagnosis, treatment or an individualized supplement recommendation.
Urolithin A is not established as a treatment for sarcopenia, cardiovascular disease, diabetes, cancer, kidney disease, liver disease or other medical conditions.
Clinical-study doses should not automatically be interpreted as personal dosage recommendations.
If you are pregnant or breastfeeding, have active cancer, are receiving cancer treatment, have significant liver or kidney disease, take prescription medications or have another complex medical condition, discuss supplement use with an appropriately qualified healthcare professional.
